SAMe or S-adenosylmethionine occurs naturally in the body and concentrates in the liver and brain. It is the main donor of the methyl group in the synthesis of hormones, nucleic acids, proteins and phospholipids. SAMe facilitates the use of glutathione and maintains the proper level of acetylcholine.

SAMe plays an important role in the immune system by maintaining cell membranes in good condition and supports the production of chemical compounds in the brain, such as serotonin, melatonin and dopamine. In addition, SAMe helps in the production of neurotransmitters in the brain, affects the mood and general well-being.SAMe is mainly used in depression. Depressed people have a reduced level of SAMe. Scientific research shows that supplementation has a positive effect on the regulation of both dopamine and serotonin levels (as well as the majority of antidepressants), and therefore may be an excellent alternative to pharmacological treatment with numerous side effects. It is also believed that SAMe helps relieve pain in cases of osteoarthritis. SAMe reduces morning stiffness, improves range of movement, reduces pain and swelling and increases walking speed. In addition, SAMe can help normalize liver enzymes in people with liver disease.

Application :

  • depression,
  • schizophrenia,
  • neurodegenerative diseases (Parkinson, Alzheimer, demyelination),
  • arthritis,
  • fibromyalgia,
  • liver cleansing,
  • liver failure.

Sources of SAMe in food:

SAMe (S-adenosylmethionine) is not present in food products.

Supplementation with SAMe:

Supplements which contain SAMe:

SAMe (S-adenosylmethionine) 200 mg, 30 tablets (Life Extension) – product available here


SAMe should not be given to children, pregnant women and breastfeeding women. SAMe should not be taken by persons with bipolar disorder. SAMe should not be used with Dextromethorphan, Meperidine (or Demerol), Pentazocine (or Talwin), Tramadol (or Ultram) and antidepressants.



People taking SAMe should take a multivitamin containing folic acid and vitamins B12 and B6.

Side effects may include dry mouth, anxiety, nausea, gas, arousal, diarrhea, headaches, anxiety and insomnia. Too high doses may cause abnormal mood swings.